Office Address
Integrated Biosciences Bldg., Room 2417
6135 Woodward Avenue
Detroit MI 48202
Position Title
Associate Professor
Biography
We focus on understanding the metabolic activities that drive both physiological processes and pathological conditions. Our research centers on two critical areas: one-carbon metabolism and triglyceride mobilization. By employing diverse research models, including biochemical assays, cell cultures, and genetically modified animals, we explore novel aspects of enzymatic function and metabolic signaling regulation within these fundamental pathways. Combining biochemistry, cell biology, and mouse genetics, our work aims to uncover mechanisms underlying human diseases, such as cancer and metabolic disorders, and to inform the development of innovative therapeutic interventions.
Education Training
M.D. (1989), Tongji Medical University, Wuhan, China
Ph.D. (2005), McGill University, Montreal, Canada
Postdoctoral fellowship (2011), University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Areas of Interest
metabolism, metabolic disease, cancer
Publications
Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J. SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice. Commun. Biol. 2024 Feb 12; 7(1):173.
Jog R, Chen G, Wang J, Leff T. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiol Rep. 2021 Aug;9(15):e14991.
Chen G, Zhou G, Lotvola A, Granneman JG, Wang J. ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway. J Biol Chem. 2021 Jan-Jun;296:100104.
Lucas S, Chen G, Aras S, Wang J. Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells. Life Sci Alliance. 2018 May;1(2):e201800036.
Chen G, Zhou G, Aras S, He Z, Lucas S, Podgorski I, Sakr W, Granneman JG, Wang J. Loss of ABHD5 promotes the aggressiveness of prostate cancer cells. Sci Rep. 2017 Oct 12;7(1):13021.
Courses taught by Jian Wang
Fall Term 2024
Winter Term 2024
Fall Term 2023
Winter Term 2022
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