Office Address
Integrated Biosciences Bldg., Room 2417
6135 Woodward Avenue
Detroit MI 48202
Position Title
Associate Professor
Biography
We are focusing on metabolism with the aim of understanding the metabolic activities important for both physiology and pathology. Specifically, we are conducting research in two areas: 1) one-carbon metabolism and 2) triglyceride mobilization. We use a variety of research models including biochemical assays, cell cultures, and genetically modified animals. Through a combination of biochemistry, cell biology, and mouse genetics, we are investigating new aspects of enzymatic function and metabolic signaling regulation in these fundamental metabolic pathways. Our research has broad implications for understanding the development of human diseases, including cancer and metabolic diseases, and for developing interventions.
Education Training
M.D. (1989), Tongji Medical University, Wuhan, China
Ph.D. (2005), McGill University, Montreal, Canada
Postdoctoral fellowship (2011), University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Areas of Interest
metabolism, metabolic disease, cancer
Publications
Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J. SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice. Commun. Biol. 2024 Feb 12; 7(1):173.
Jog R, Chen G, Wang J, Leff T. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiol Rep. 2021 Aug;9(15):e14991.
Chen G, Zhou G, Lotvola A, Granneman JG, Wang J. ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway. J Biol Chem. 2021 Jan-Jun;296:100104.
Lucas S, Chen G, Aras S, Wang J. Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells. Life Sci Alliance. 2018 May;1(2):e201800036.
Chen G, Zhou G, Aras S, He Z, Lucas S, Podgorski I, Sakr W, Granneman JG, Wang J. Loss of ABHD5 promotes the aggressiveness of prostate cancer cells. Sci Rep. 2017 Oct 12;7(1):13021.
Courses taught by Jian Wang
Fall Term 2024 (current)
Winter Term 2024
Fall Term 2023
Winter Term 2022
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