Menq-jer Lee, Ph.D.

Menq-jer Lee, Ph.D.

(313) 577-9473

Menq-jer Lee, Ph.D.

Office Address

Department of Pathology 

9213 Scott Hall

540 East Canfield Ave.
Detroit, MI 48201


Administrative Contact

Christoper Harris
Phone: (313) 577-1018

Position Title

Associate Professor

Education Training

Ph.D. (1993): McGill University, Montreal, Canada

Postdoctoral Fellowship
1994-1996: The Holland Laboratory/American Red Cross, Rockville, MD, USA
1996-1999: University of Connecticut Health Science Center, Farmington, CT, USA

Areas of Interest

Cancer and cardiovascular diseases


Research Interests

Sphingolipids, signal transduction, GPCR, angiogenesis, vascular biology, EMT, and tumorgenesis.


1. Lee JF, Gordon S, Estrada R, Wang L, Siow DL, Wattenberg BW, Lominadze D, and MJ Lee, 2009, Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature, Am J Physiol Heart Circ Physiol, 296: H33-H42.

2. Estrada R, Wang L, Jala VR, Lee JF, Lin CY, Gray RD, Haribabu B, and MJ Lee, 2009, Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells, Histochem Cell Biol, 131: 239-51.

3. MA Eskan, BG Rose, MR Benakanakere, MJ Lee, and DF Kinane, 2008, Sphingosine 1-phosphate 1 and TLR4 mediate IFN- expression in human gingival epithelial cells, J Immunol, 180: 1818-25.

4. Estrada R, Zeng Q, Lu H, Sarojini H, Lee JF, Mathis SP, Sanchez T, Wang E, Kontos CD, Lin CY, Hla T, Haribabu B, and MJ Lee, 2008, Up-regulating sphingosine-1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells, J Biol Chem, 283: 30363-75.

5. JF Lee, Q Zeng, H Ozaki, L Wang, AR Hand, T Hla, E Wang, and MJ Lee, 2006, Dual roles of tight junction associated protein, Zonula Occludens-1, in sphingosine-1-phosphate regulated endothelial barrier integrity and wound-healing response, J Biol Chem, 281:29190-29200.

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