Office Address

Vattikuti Urology Institute
Henry Ford Health System
1 Ford Place
Detroit, MI, 48202

Position Title

Professor

Education Training

• B.Sc., Biological & Physical Sciences, Osmania University, India 1968
• M.Sc., Genetics, Osmania University, India 1971
• Ph.D., Molecular Biology and Biochemistry, University of Arizona, Tucson, AZ 1978
• Post-Doc, Pharmacology, Harvard Medical School, Boston, MA 1978-1981

Areas of Interest

Prostate cancer, calcium signaling, androgen receptor, cell cycle and molecular markers

Publications

Following is a partial listing of peer-reviewed articles and book chapters

• Reddy, G.P.V., A.Singh, M.E.Stafford, and C.K.Mathews (1977); Enzyme associations in T4 phage DNA precursor synthesis. Proc. Natl. Acad. Sci., USA, 74, 3152-3156.
• Reddy, G.P.V., and C.K.Mathews (1978); Functional compartmentation of DNA precursors. J. Biol. Chem. 253, 3461-3467.
• Reddy, G.P.V., and A.B.Pardee (1980);A multienzyme complex for metabolic channeling in mammalian DNA replication. Proc. Nat. Acad. Sci., USA, 77, 3312-3316.
• Allen,R., Reddy, G.P.V., G.C.Laser, and C.K.Mathews (1980); T4 Ribonucleotide reductase -- Physical and kinetic linkage to other enzymes of deoxyribonucleotide biosynthesis. J. Biol. Chem., 225, 7583-7588.
• Reddy, G.P.V. and A.B.Pardee (1982); Coupled ribonucleoside diphosphate reduction, Channeling and incorporation into DNA of Mammalian cells. J. Biol.Chem. 257, 12526-12531.
• Reddy, G.P.V. (1982); Catalytic function of thymidylate synthase is confined to S Phase due to its association with replitase. Biochem. Biophys. Res. Comm., 109, 908-915.
• Noguchi, H., Reddy, G.P.V. and Arthur B.Pardee (1983); Rapid incorporation of the label from ribonucleoside diphosphates into DNA by a cell-free high molecular weight fraction from nuclei of animal cells. Cell, 32, 443-451.
• Reddy, G.P.V. and Arthur B.Pardee (1983); Inhibitor evidence for allosteric interaction in the replitase multienzyme complex. Nature, 304, 86-88.
• Reddy, G.P.V., E.M.Klinge, and Arthur B.Pardee (1986); Ribonucleotides are channeled into a mixed DNA-RNA polymer by permeabilized hamster cells. Biochem. Biophys. Res. Comm., 135, 340-346.
• Hammond,R.A., Miller, M.R., Gray, M.S., and Reddy, G.P.V. (1989); Association of 3'--5' exodeoxyribonuclease activity with DNA replitase complex from S phase Chinese hamster embryo fibroblast cells. Exp. Cell Res., 183, 284-293.
• Subramanyam,C., Honn,S.C., Reed,W.C., and Reddy, G.P.V. (1990) Nuclear localization of 68 kDa CaM-BP is associated with the onset of DNA replication. J. Cell. Phys., 144, 423-428.
• Plucinski, T., Fager, R.S., and Reddy, G.P.V. (1990); Allosteric interaction of components of the replitase complex are responsible for enzyme cross-inhibition. Mol. Pharm., 38, 114-120.
• Studzinski,G.P., Shankavaram,U.T., Moore,D.C., and Reddy, G.P.V. (1991) Association of C-myc protein with enzymes of DNA replication in high molecular weight fractions from mammalian cells. J. Cell. Phys., 147, 412-419.
• Reddy, G. P.V., Reed, W.C., Deacon, D., and Quesenberry, P.J. (1992) Growth factor-dependent proliferative stimulation of hemopoietic cells is associated with the modulation of cytoplasmic and nuclear 68 kDa calmodulin-binding protein. Blood, 79, 1946-1955.
• Reddy, G. P.V., Reed, W.C., Sheean, E., and Sacks, D.B. (1992) Calmodulin-specific monoclonal antibodies inhibit DNA replication in mammalian cells. Biochem., 39, 10426-10430.
• Reddy, G. P.V., Reed, W.C., Deacon, D., and Quesenberry, P.J. (1994) Growth factor modulated calmodulin-binding protein stimulates nuclear DNA synthesis in hemopoietic progenitor cells. Biochem., 33, 6605-6610.
• Jaumot,M., Grana,X., Reddy, G. P.V., Agell,N, and Bachs,O. (1994) Cyclin/CDK2 complexes in the nucleus of HeLa cells, Biochem. Biophys. Res. Commun., 203, 1527-1534.
• Reddy, G. P.V. (1994) Cell cycle: Regulatory events in G1?S transition of mammalian cells. J. Cell. Biochem., 54, 379-386.
• Cao, Q.P., C.A.McGrath, E.F.Baril, P.J.Quesenberry, and Reddy, G.P.V. (1995) The 68 kDa calmodulin-binding protein is tightly associated the multiprotein DNA polymerase ?-primase complex in HeLa cells, Biochemistry, 34, 3878-3883.
• Quesenberry, P.J., Iscove, N.N., Cooper, C., Brady, G., Newberger, P., Stein, G.S., Stein, J.L., Reddy, G. P.V., Pearson-White, S. (1996) Expression of basic helix-loop-helix transcription factors in explant hematopoietic progenitors. J. Cell. Biochem, 61, 478-488.
• Reddy, G.P.V., Quesenberry, P.J. (1996) Stem cell factor enhances interleukin-3-dependent induction of CaM-BP68 and thymidine kinase activity in NFS-60 cells, Blood, 87, 3195-3202.
• Maramag, C., Menon, M., Balaji, K.C., Reddy, G.P.V., Laxmanan, S. (1997) Effect of vitamin C on prostate cancer cells in vitro: Effect on cell number, viability, and DNA synthesis. The Prostate, 32, 188-195.
• Balaji, K.C., Koul, H., Mitra, S., Maramag, C., Reddy, G.P.V., Menon, M., Malhotra, K., Laxmanan, S. (1997): Anti-proliferative effects of c-myc antisense oligonucleotides in prostate cancer cells: A novel therapy for prostate cancer. Urology, 50, 1007-1015.
• Reddy, G.P.V., Tiarks, C.Y., Pang, L., Quesenberry, P.J. (1997) Synchronization and cell cycle analysis of pluripotent hematopoietic stem cells. Blood, 90, 2293-2299.
• Biswas,D.K., Reddy, G.P.V., Pickard, M., Makkad, B., Pettit, N., Pardee, A.B. (1998) Calmodulin is essential for estrogen receptor interaction with its motif and activation of responsive promoter. J. Biol. Chem. 273, 33817-33824.
• Kuwajerwala N, Cifuentis-Pagano E, Gautam S, Menon M, Barrack ER, Reddy GPV (2002) Resveratrol induces prostate cancer cell entry into S and inhibits DNA synthesis. Can. Res. 62: 2488-2492.
• Reddy GPV, McAuliffe CI, Pang L, Quesenberry PJ, Bertoncello I (2002): Cytokine receptor repertoire and cytokine responsiveness of HODull/RHDull stem cells with differing potentials for G1/S phase progression. Exp Hematol 30: 793-801.
• Cifuentes-Pagano E, Croxen R, Menon M, Barrack ER, Reddy GPV, (2003): Synchronized prostate cancer cells for studying androgen regulated events in cell cycle progression from G1 into S phase. J Cell Physiol 195:337-345.
• Pang L, Reddy GPV, McAuliffe CI, Colvin G, Quesenberry, PJ (2003) Studies on BrdU labeling of hematopoietic cells: stem cells and cell lines. J Cell Physiol 197:251-260.
• Pardee, A.B., and Reddy GPV (2003): Beginnings of feedback inhibition, allostery and multi-protein complexes. Genes 321:17-23.
• Ding D, Xu L, Menon, M, Reddy GPV, Barrack ER (2004): Effect of normal polymorphic CAG (glutamine) repeat length on human androgen receptor function. The Prostate 58: 23-32.
• Cifuentes E, Mataraza JM, Yoshida B, Menon M, Sacks DB, Barrack ER, Reddy GPV (2004): Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells. Proc Nat Acad Sci USA 101:464-469.
• Pardee AB, Li CJ, Reddy GPV (2004): Regulation in S phase by E2F. Cell Cycle 3:1091-1094.
• Ding D, Xu L, Menon M, Reddy GPV, Barrack ER (2005): Effect of GGC (glycine) repeat length polymorphism in the human androgen receptor on androgen action. The Prostate 62(2):133-139.
• Bai VU, Cifuentes, E, Menon M, Barrack ER, Reddy GPV (2005) Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S Phase. J Cell Physiol 204:381-387.
• Wang A, Li CJ, Reddy GPV, and Pardee AB (2005) Cancer chemotherapy by deoxynucleotide depletion and E2F-1 elevation. Can Res 65:7809-7814.
• Murthy S, Reddy GPV (2006) Replitase: complete machinery for DNA synthesis. J Cell Physiol 209:711-717.
• Reddy GPV, Barrack ER, Dou QP, Menon M, Pelley RP, Sarkar FH, Sheng S (2006) Regulatory processes affecting androgen receptor expression, stability, and function: potential targets to treat hormone refractory prostate cancer. J Cell Biochem 98:1408-1423.
• Pelley RP, Chinnakannu K, Murthy S, Strickland FM, Menon M, Dou QP, Barrack ER, Reddy GPV (2006) Calmodulin-androgen receptor interaction: calcium-dependent, calpain-mediated breakdown of androgen receptor in LNCaP prostate cancer cells. Can Res 66: 11754-11762.
• Chen D, Cui QC, Yang H, Barrea RA, Sarkar FH, Sheng S, Yan B, Reddy GPV, Dou QP (2007) Cliquinol, a therapeutic agent for alzheimer’s disease, has proteasome-inhibitory, apoptosis-inducing and anti-tumor activities in human prostate cancer cells and xenografts. Can Res 67 (4): 1636 – 1644.
• Bai VU, Kaseb A, Tejwani S, Divine GW, Barrack ER, Menon M, Pardee AB, Reddy GPV (2007) Identification of prostate cancer mRNA markers by averaged differential expression and their detection in biopsies, blood, and urine. Proc Nat Acad Sci, USA, 104: 2343 - 2348.
• Li X, Chen D, Yin S, Meng Y, Yang H, Landis-Piwowar KR, Li Y, Sarkar FH, Reddy GPV, Dou QP, Sheng S (2007) Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells J Cell Physiol 212(2):298-306.
• Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GPV, and Sarkar FH (2007); Regulation of FOXO3a/?-catenin/GSK-3? signaling by 3,3’-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem 282:21542-50.
• Kaseb H, Chinnakannu K, Chen D, Sivanandam A, Tejwani S, Menon M, and Reddy GPV (2007) Androgen receptor- and E2F-1- targeted thymoquinone therapy for hormone-refractory prostate cancer. Can Res 67:7782-88.
• Yang H, Landis-Piwowar K, Lu D, Yuan Y, Li L, Reddy GPV, Yuan X, and Dou P (2008): Pristimerin is a natural proteasome inhibitor and apoptosis inducer in prostate cancer cells. J Cell Biochem 103:234-244.
• Yang H, Murthy S, Sarkar FH, Sheng S, Reddy GPV, Dou P (2008) Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells. J Cell Physiol 217:569-576.
• Siva S, Barrack ER, Reddy GPV, Thamilselvan V, Thamilselvan S, Menon M, and Bhandari M (2008) A Critical Analysis of the Role of Gut Oxalobacter formigenes in Oxalate Stone Disease. BJU International (in press)
• Chinnakannu K, Chen D, Li Y, Wang Z, Dou P, Reddy GPV and Sarkar FH (2008) Cell cycle-dependent effects of 3,3?-diindolylmethane on proliferation and apoptosis of prostate cancer cells. J Cell Physiol (in press)
• Murthy S, Chinnakannu K, Menon M, Barrack R, Reddy GPV (2009): Role of androgen receptor in progression of prostate cancer cells from G1 into S phase and the onset of DNA synthesis (in preparation).

Book Chapters and Review Articles

• Reddy GPV (1991) Allosteric interaction between the enzymes of DNA biosynthesis in mammalian cells. MBL Lectures in Biology, Eds. M.Inouye, J.Campisi, D.Cunningham, and M.Riley. John Wiley & Sons, Inc., pp. 315-329.
• Reddy GPV and Roger S. Fager (1993) Replitase: A complex integrating dNTP synthesis and DNA replication. Crit. Rev. Euk. Gene Expre, 3, (4), 255-277.
• Reddy GPV (1994) Cell cycle: Regulatory events in G1?S transition of mammalian cells. J. Cell. Biochem., 54, 379-386.
• Reddy GPV (1998) Regulation of DNA replication and S phase. In: The Molecular Basis of Cell Cycle and Growth Control. Editors: Stein GS, Besarga R, Giordano A, and Denhardt DT. Wiley-Liss Inc., Pages 80-154.
• Reddy GPV, Cifuentes E, Menon, M, Barrack ER (2002): Steroid hormone and growth factor interaction in the regulation of cell cycle progression. In Steroid Hormones and Cell Cycle Regulation (Editor K.L. Burnstein). Kluwer Academic Publisher, Norwell, MA, pp 111 - 135.
• Reddy GPV, Cifuentes E, Bai, VU, Menon, M, Barrack ER (2004): Onset of DNA synthesis and S phase. In Cell Cycle and Growth Control: Biological Regulation and Cancer (Editors G.Stein and AB. Pardee) John Wiley & Sons, Inc., Pages 149-200.

Other Information

Activities/Membership

• 1992, 1993, Site Visit Committe Member for NIH, NCI
• 1993, Special Review Committee Member for NIH, NCI (RFA CA-92-22)
• 1993, Special Review Committee Member for NIH, NIDDK (RFA DK-94-05)
• 1984 -present, Member of American Society of Biological Chemists
• 1982 -present, Member of American Association for the Advancement of Science
• 2002 -present, Member of American Association for Cancer Research
• 2004-present, Member of Editorial Board of the Journal of Cellular Biochemistry

Journal Reviewer

• Experimental Hematology
• Journal of Biological Chemistry
• Journal of Cellular Biochemistry
• Biochimica et Biophysica Acta
• J of Urology, Cancer Research

United States Patent

• Peter J. Quesenberry and G. Prem-Veer Reddy: Hematopoietic Growth-Regulatory Calmodulin-Binding Protein and Methods of Using the Same. US Patent Number: 5,583,199. Date of Patent: December 10, 1996.

 

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