Edi Levi
Office Address
Department of PathologyJohn Dingell VA Medical Center
Detroit, MI 48201
Position Title
Associate ProfessorBiography
Dr. Levis subspecialty expertise is in the field of hematologic cancers, lymphomas and leukemias. Dr. Levi also runs the Flow Cytometry Facility at the Detroit VA Medical Center.
Education Training
M.D (1986)
Hacettepe University Medical School
Ankara, Turkey
PhD in Physiology (1990)
Hacettepe University Medical School
Ankara, Turkey
Postdoctoral Fellowship (1990-1992)
University of Southern California
Los Angeles, CA, USA
Hematopathology Fellowship (1996-1997)
Beth Israel-Deaconess Medical Center
Boston, MA, USA
Research Fellowship in Hematopathology (1997-1999)
Beth Israel-Deaconess Medical Center
Boston, MA, USA
Medical Education Responsibilities
Undergraduate Program:
Lab instructor in 2nd year Medical School Students Pathology Courses
Others:
Member of the medical IRB (M1), Wayne State University, 2004-current
Member of the Clinical Investigation Committee, John Dingell VAMC. 2004-current
Areas of Interest
Cancer, molecular diagnosis and prognosisExpertise: Surgical Pathology, Hematopathology
Research
Dr. Levi is interested in the biology of gastrointestinal cancers, specifically on the role of cancer stem cells in the pathogenesis of cancers and precursor lesions such as colon polyps and gastric Helicobacter Pylori associated gastritis. Recently we have demonstrated increased expression of cancer stem cells in aging and in response to experimental carcinogenesis utilizing an animal model. We have expanded our studies to precursor lesions in the stomach and have also demonstrated that H. Pylori infection causes an increase in the expression of cancer stem cells in gastric mucosa. Our current and future projects are focused on isolation, quantitation and analysis of cancer stem cells and investigate their prognostic significance. We are utilizing immunohistochemical, molecular and flow cytometric methods to achieve our goals. The study group includes Dr. Adhip Majumdar and Dr. Bhaumik Patel from the Department of Medicine and Oncology.
Research Interests
Gastrointestinal Cancers and Lymphomas
Residency
Anatomic Pathology Residency (1992-1996)
Northwestern University Medical School
Chicago, IL, USA
Publications
1: Levi E, Majumdar AP. Cancer stem cells in ulcerative colitis. Onkologie. 2011;34(12):660-2. doi: 10.1159/000334812. Epub 2011 Nov 21. PubMed PMID: 22156444.
2: Nautiyal J, Du J, Yu Y, Kanwar SS, Levi E, Majumdar AP. EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine. Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G655-63. doi: 10.1152/ajpgi.00323.2011. Epub 2012 Jan 26. PubMed PMID: 22281474; PubMed Central PMCID: PMC3330776.
3: Roy S, Levi E, Majumdar AP, Sarkar FH. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J Hematol Oncol. 2012 Sep 19;5:58. doi: 10.1186/1756-8722-5-58. PubMed PMID: 22992310; PubMed Central PMCID: PMC3464169.
4: Levi E, Misra S, Du J, Patel BB, Majumdar AP. Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of rat colonic crypts. Biochem Biophys Res Commun. 2009 Jul 31;385(3):430-3. doi: 10.1016/j.bbrc.2009.05.080. Epub 2009 May 22. PubMed PMID: 19465005; PubMed Central PMCID: PMC2735198.
5: Patel BB, Yu Y, Du J, Levi E, Phillip PA, Majumdar AP. Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer. Biochem Biophys Res Commun. 2009 Jan 16;378(3):344-7. doi: 10.1016/j.bbrc.2008.10.179. Epub 2008 Nov 14. PubMed PMID: 19010307; PubMed Central PMCID: PMC2644999.