Todd Leff
Office Address
Lab: Integrative Biosciences Center
6135 Woodward Avenue
Detroit, MI 48202
(313)577-3006
Graduate School: Maccabees Building, rm. 6305.5
5057 Woodward Avenue
Detroit, MI 48202
(313)577-8002
Position Title
Associate Dean, Graduate School
Associate Professor, Pathology
Wayne State University
Areas of Interest
Molecular and cellular biology of metabolism and type II diabetesResearch
Gene transcription, nuclear receptors, metabolic regulation, insulin resistance, and diabetes
Publications
1. Hong YH, Varanasi US, Yang W and Leff T, 2003, AMP-activated protein kinase regulates HNF4α transcriptional activity by inhibiting dimmer formation and decreasing protein stability, J Biol Chem, 278: 27495-501.
2. Hegele RA and Leff T, 2004, Unbuckling lipodystrophy from insulin resistance and hypertension, J Clin Invest, 114: 163-5.
3. Li G & Leff T, 200, Altered promoter recycling rates contribute to dominant/negative activity of human PPAR γ mutations associated with diabetes, Mol Endocrinol, 21: 857-64.
4. Monajemi H, Zhang L, Li G, Cao H, Maas M, Brouwer CB, Kalkhoven E, Stroes E, Hegele RA, and Leff T, 2007, Familial partial lipodystrophy phenotype resulting from a single-base mutation in DNA binding domain of peroxisome proliferator-activated receptor gamma, J Clin Endocrinol Metab, 92: 1606-12.
Courses taught by Todd Leff
Winter Term 2025 (future)
Fall Term 2024 (current)
- GS0900 - Essential Research Practices: Responsible Conduct of Research
- IM7040 - Fundamentals of Research
Winter Term 2024
- MGG7091 - Scientific Communication
- GS0900 - Essential Research Practices: Responsible Conduct of Research
Fall Term 2023
- MGG7020 - Metabolism and Disease
- GS0900 - Essential Research Practices: Responsible Conduct of Research
- PTH7890 - Seminar