Krishna Rao Maddipati
Krishna Rao Maddipati
435 Chemistry Bldg.
5101 Cass Ave.
Wayne State University
Detroit, MI 48202
Administrative ContactBrenda Batts
Phone: (313) 577-8144
Position TitleAssociate Professor, Director of Lipidomics Core Facility
Ph.D. (1983): Indian Institute of Science, Bangalore, India
Research Associate, The Pennsylvania State University, University Park, PA (1983-85)
Research Scientist, Wayne State University, Detroit, MI (1985-89)
Areas of InterestLipidomics, Anticancer agents, PUFA Metabolism
Mass Spectrometry based lipidomics, Anticancer drug development, Bioactivelipid metabolism, and inflammation
Dr. Maddipati is primarily interested in evaluating the role of bioactive lipids, especially metabolites of polyunsaturated fatty acids, in inflammation and related diseases. These include metabolites of ω-6 and ω-3 fatty acids by lipoxygenases such as HETEs, leukotrienes, lipoxins, resolvins, and protectins. Identification of lipid biomarkers in cancer and inflammatory diseases by LC-MS, anticancer drug development targeting arachidonate 12-lipoxygenase, and identification of anticancer and anti-inflammatory compounds in dietary ingredients to provide a biochemical rationale for their beneficial effects are other areas of research interest to our group.
Dr. Maddipati also directs the Lipidomics Core Facility.
Yang, T., Xu, G., Newton, P.T., Chagin, A.S., Mkrtchian, S., Carlstrom, M., Zhang, X.M., Harris, R.A., Cooter, M., Berger, M., Maddipati, K.R., Akassoglou, K., Terrando, N., Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. Br. J. Anaesth. 122 (2019) 350-360
Warner, D.R., Warner, J.B., Hardesty, J.E., Song, Y.L., King, T.N., Kang, J.X., Chen, C.Y., Xie, S., Yuan, F., Prodhan, M.A.I., Ma, X., Zhang, X., Rouchka, E.C., Maddipati, K.R., Whitlock, J., Li, E.C., Wang, G.P., McClain, C.J., Kirpich, I.A., Decreased omega-6:omega-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury. J. Lipid Res. 60 (2019) 2034-2049 [PubMedID: PMC6889711]
Norris, P.C., Skulas-Ray, A.C., Riley, I., Richter, C.K., Kris-Etherton, P.M., Jensen, G.L., Serhan, C.N., Maddipati, K.R., Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation. Sci Rep 8 (2018) 18050 [PubMedID: 6396737]
Maddipati, K.R., Romero, R., Chaiworapongsa, T., Chaemsaithong, P., Zhou, S.-L., Xu, Z., Tarca, A.L., Kusanovic, J.P., Gomez, R., Docheva, N., Honn, K.V., Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome. J. Lipid Res. 57 (2016) 1906-1916
Maddipati, K.R., Romero, R., Chaiworapongsa, T., Zhou, S.L., Xu, Z., Tarca, A.L., Kusanovic, J.P., Munoz, H., Honn, K.V., Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor. FASEB J. 28 (2014) 4835-4846 [PubMedID: 4200329]
Maddipati, K.R., Zhou, S.L., Stability and analysis of eicosanoids and docosanoids in tissue culture media. Prostaglandins Other Lipid Mediat. 94 (2011) 59-72 [PubMedID: 21236355]