Krishnarao Maddipati
Office Address
435 Chemistry Bldg.
5101 Cass Ave.
Wayne State University
Detroit, MI 48202
Position Title
Professor, Director of Lipidomics Core Facility
Education Training
Ph.D. (1983): Indian Institute of Science, Bangalore, India
Research Associate, The Pennsylvania State University, University Park, PA (1983-85)
Research Scientist, Wayne State University, Detroit, MI (1985-89)
Areas of Interest
Lipidomics, Inflammation, PUFA Metabolism, Lipid homeostasis, Unalamation
Research
Mass Spectrometry based lipidomics, Anticancer drug development, Bioactivelipid metabolism, and inflammation
Research Interests
Dr. Maddipati is primarily interested in evaluating the role of bioactive lipids, especially metabolites of polyunsaturated fatty acids, in inflammation and unalamation (un-ala-mation; maintenance of homeostasis from lipid mediator balance). These include metabolites of ω-6 and ω-3 fatty acids by all three major pathways of PUFA metabolism, viz., Cyclooxygenase, Lipoxygenase, and the Cytochrome P450. Identification of lipid biomarkers in cancer and inflammatory diseases by LC-MS and identification of anticancer and anti-inflammatory compounds in dietary ingredients to provide a biochemical rationale for their beneficial effects are other areas of research interest to his group.
Current Lab Personnel
Mr. Yinlong Cai, Lab Manager
Mr. Jianwei Ren, Research Assistant
Dr. Govindaiah Pilli, Postdoctoral Fellow
Publications
Maddipati KR. Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy. Frontiers in Immunology. 2024;15
Maddipati, K.R., Non-inflammatory Physiology of "Inflammatory" Mediators - Unalamation, a New Paradigm. Front Immunol 11 (2020) 580117 [PubMedID: PMC7575772]
Yang, T., Xu, G., Newton, P.T., Chagin, A.S., Mkrtchian, S., Carlstrom, M., Zhang, X.M., Harris, R.A., Cooter, M., Berger, M., Maddipati, K.R., Akassoglou, K., Terrando, N., Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. Br. J. Anaesth. 122 (2019) 350-360
Warner, D.R., Warner, J.B., Hardesty, J.E., Song, Y.L., King, T.N., Kang, J.X., Chen, C.Y., Xie, S., Yuan, F., Prodhan, M.A.I., Ma, X., Zhang, X., Rouchka, E.C., Maddipati, K.R., Whitlock, J., Li, E.C., Wang, G.P., McClain, C.J., Kirpich, I.A., Decreased omega-6:omega-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury. J. Lipid Res. 60 (2019) 2034-2049 [PubMedID: PMC6889711]
Maddipati, K.R., Romero, R., Chaiworapongsa, T., Chaemsaithong, P., Zhou, S.-L., Xu, Z., Tarca, A.L., Kusanovic, J.P., Gomez, R., Docheva, N., Honn, K.V., Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome. J. Lipid Res. 57 (2016) 1906-1916
Maddipati, K.R., Romero, R., Chaiworapongsa, T., Zhou, S.L., Xu, Z., Tarca, A.L., Kusanovic, J.P., Munoz, H., Honn, K.V., Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor. FASEB J. 28 (2014) 4835-4846 [PubMedID: 4200329]
Maddipati, K.R., Zhou, S.L., Stability and analysis of eicosanoids and docosanoids in tissue culture media. Prostaglandins Other Lipid Mediat. 94 (2011) 59-72 [PubMedID: 21236355]
Click the link for a complete list of publications of Dr. Maddipati