Office address

3990 John R
Harper University Hospital, Department of Pathology
Detroit, MI 48201

Academic title

Professor

Education training

1978-1985 M.D. (summa cum laude), 2nd Medical School, Naples, Italy

1986-1987 Guest Researcher, Laboratory of Cellular and Molecular Biology NCI, Bethesda, MD

1987-1990 Fogarty International fellow, Laboratory of Cellular and Molecular Biology NCI, Bethesda, MD

1990-1993 Residency in Anatomic Pathology, University of Rochester Medical Center, Rochester, NY

1993-1994 Wilmot Cancer Research fellow, University of Rochester Medical Center, Rochester, NY

1994-1995 Oncologic Anatomic Pathology Fellow, Memorial Sloan Kettering Cancer Center, NYC

1995-1999 Experimental Pathology Fellow, Memorial Sloan Kettering Cancer Center, New York, NY

Areas of interest

Pulmonary Carcinogenesis, Molecular Pathogenesis of Lung Adenocarcinoma, Epidemiology of Lung Cancer, Role of Maspin in Lung Cancer

Research

Together with S. Sheng, PhD. (Pathology), I have found that an exclusively nuclear expression, compared to a combined nuclear-cytoplasmic expression of the tumor suppressor protein maspin is common in adenocarcinoma, but not in squamous cell carcinoma of the lung. In addition, in limited stage adenocarcinoma nuclear maspin is linked with favorable clinical-pathological variables, including  improved survival. These data, along with in vitro evidence, support the hypothesis that maspin's tumor suppressor ability depends on its nuclear localization. Ongoing research investigates the role of changes in maspin cellular localization in morphological progression in lung adenocarcinoma and its biochemical basis.

I am also involved in a prospective epidemiological study with Ann Schwartz PhD. (Internal Medicine) to address the hypothesis that gene polymporphisms in inflammatory genes may explain relative propensity to develop COPD vs. lung cancer in smokers.

In collaboration with G. Hillmann, PhD. (Radiology),  I am studying a mice model of lung cancer to evaluate compounds with chemotherapeutic or radiation damage-protective activity.

Research interests

Molecular pathogenesis of lung cancer

Relations between molecular and morphological features of lung cancer

Epidemiological aspects of lung cancer

Recent publications

Trendowski MR, Watza D, Lusk CM, Lonardo F,Ratliff V, Wenzlaff AS, Mamdani H, Neslund-Dudas C, Boerner JL, Schwartz A, Gibson HM: Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer Cancer Epidemiol Biomarkers Prev OF1–OF9,July 31 2024.

Representative accomplishments

1. Lonardo F, Guan H, Dzinic S, and Sheng S: Maspin Expression Patterns Differ in the Invasive vs. Lepidic Growth Pattern of Pulmonary Adenocarcinoma. Histopathology 2014 Jul 5. doi: 10.1111/his.12485. PMID: 25040445.
2. Dzinic SH, Bernardo MM, Li X, Fernandez-Valdivia R, Ho YS, Mi QS, Bandyopadhyay S, Lonardo F,Vranic S, Oliveira DS, Bonfil RD, Dyson G, Chen K, Omerovic A, Sheng X, Han X, Wu D, Bi X, Cabaravdic D, Jakupovic U, Wahba M, Pang A, Harajli D, Sakr WA, Sheng S. An Essential Role of Maspin in Embryogenesis and Tumor Suppression. Cancer research. 2017; 77(4):886-896. NIHMSID: NIHMS835433
3. Trendowski MR, Watza D, Lusk CM, Lonardo F,Ratliff V, Wenzlaff AS, Mamdani H, Neslund-Dudas C, Boerner JL, Schwartz A, Gibson HM: Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer Cancer Epidemiol Biomarkers Prev OF1–

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