Office AddressWayne State University - Karmanos Cancer Institute
Karmanos Cancer Institute
3115 Prentis Building
110 East Warren Avenue
Detroit, Michigan 48201
Ph.D., Cornell University, 1977
Areas of InterestBasic mechanisms of molecular and cellular biology that are altered as cells progress to become neoplastic
The research focus of the lab is based on our research experience in inherited cancer and genomic instability. Finding the Cancer Early. We have developed technology for a new biochip-based test for cancer that can predict cancer before there are symptoms. Protein microarrays containing thousands of proteins are used in screening tests for breast and ovarian cancer. Understanding Cells with Defective, Mutant Cancer Genes. We discovered over 20 years ago that cells with defects in cancer predisposing genes grow abnormally in the laboratory. Using genomic profiling we have identified 3 genetic pathways that contribute to immortalization of cancer cells. These pathways are being studied to develop new therapies for the early interference in cancer formation in patients genetically predisposed to the disease.
Draghici, S., Chatterjee, M. Tainsky, M.A. Epitomics: Serum screening for the early detection of cancer on microarrays using complex panels of tumor antigens, Expert Reviews in Molecular Diagnostics, 5:735-743, 2005.
Tang, L., Roberts, P.C., Kraniak, J.M., Li, Q., and Tainsky, M.A. STAT1 expression is not sufficient to regulate interferon-signaling pathway in cellular immortalization, J Interferon & Cytokine Res. 26: 14-26, 2006.
Fridman, A.L., Tang, L., Kulaeva, O.I., Ye, B., Li, Q., Nahhas, F., Land, S.J., Roberts, P.C., Abrams, J., and Tainsky, M.A. Expression Profiling Identifies Three Pathways Altered in Cellular Immortalization: Interferon, Cell Cycle and Cytoskeleton. J Gerontol A Biol Sci Med Sci. 61:879-89, 2006.
Chatterjee, M., Mohapatra, S., Wang, X., Nowak, J., Nahhas, A.F., Lu, K., Witkin, S.S, Fishman, D., Munkarah, A., Morris, R., Levin, K.N., Tromp, G., Abrams, J., Draghici, S., and Tainsky, M.A. Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays. Cancer Research, 66: 1181-90, 2006.
Xu, J., Zhou, J.Y., Tainsky, M.A., Wu, G.S. Evidence that Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induction by 5-Aza-2'-Deoxycytidine Sensitizes Human Breast Cancer Cells to Adriamycin. Cancer Res. 67:1203-11, 2007.
Munkarah, A., Chatterjee, M., Tainsky, M.A. Update on Ovarian Cancer Screening. Current Opinion Obstet Gynecol. 10:22-6, 2007.
Fridman, A.L., Rosati, R., Li, Q., and Tainsky, M.A. Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalization, Biochemical and Biophysical Research Communications, 357:785-791, 2007.
Separovica, D. Hanada, K. Maitah, MYA. Nagy, B. Hang, I, Tainsky, MA. Kraniak, JM. Bielawski, J. Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage, Biochemical and Biophysical Research Communications, 358: 196-202, 2007.
Nahhas, F. Dryden, S.C., Abrams, J., and Tainsky, M.A. Phosphorylation of SIRT2 Deacetylase Does not Regulate its Interaction with HDAC6 and Tubulin, Molecular and Cellular Biochemistry, In Press. E-Pub online, May 22, 2007.
Tainsky, MA, Chatterjee, M, Levin, NK, Draghici, S, and Abrams, J. Multianalyte Tests for the Early Detection of Cancer: Speedbumps and Barriers, Biomarkers Insights, In Press, 2007.
Li, Q., Tang, L., Roberts, P.C., Kraniak, J.M., Fridman, A., Kulaeva, O., Tehrani, O., and Tainsky, M.A. Interferon Regulatory Factors Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts. In Press, 2007.