Sreenivasa R.  Chinni, Ph.D.

Sreenivasa R. Chinni, Ph.D.

schinni@med.wayne.edu

(313) 577-1833Fax: (313) 577-0057

Sreenivasa R. Chinni, Ph.D.

Office Address

Department of Urology,Pathology , abd Oncology 
9200 Scott Hall
540 E. Canfield Ave.
Detroit, MI 48201

Administrative Contact

Marlene Thompson
Phone: (313) 577- 4871

Position Title

Associate Professor of Urology and Pathology

Education Training

Ph.D. (1998): University of Louisville, School of Medicine, Louisville, KY, USA

Postdoctoral Fellowship
1998-2002: Wayne State University, Detroit, MI, USA, in the field of Cancer Biology and Chemoprevention
 

Areas of Interest

Cancer

Research

Research Interests

Prostate Cancer, chromosomal alterations, chemokine and chemokine receptors, and cell signaling and metastasis.

Publications

1. Chinni SR, Li Y, Upadhyay S, Koppolu PK and Fazlul H. Sarkar, 2001, Indole-3-Carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells, Oncogene, 20: 2927-36.

2. Chinni SR
, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD and Cher ML, 2006, CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12, Prostate, 66: 32-48.

3. Bonfil RD, Sabbota A, Nabha S, Dong Z, Meng H, Yamamoto H, Chinni SR, Bernardo MM, Lim IT, Chang M, Filetti LC, Mobashery S, Cher ML, and Fridman R, 2006, Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor, Intl J Cancer, 118: 2721-6.

4. Bonfil, RD, Chinni, SR, Fridman, R, Kim, H-R, Cher, ML, 2007, Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis, Urology Oncol, 25: 407-11.

5. Chinni, SR, Dong Z, Hamilto Y, Bonfil RD, and Cher ML, 2008, CXCL12/CXCR4 trans-activates HER2 in lipid rafts of PC cells and promotes in vivo intra-osseous tumor growth. Mol Cancer Res, 6: 446-57.
 

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