Hyeong-Reh Kim

Hyeong-Reh Kim



Hyeong-Reh Kim

Office Address

Department of Pathology
Scott Hall, Room 9271
540 East Canfield Avenue
Detroit, MI 48201

Position Title


Education Training

Ph.D. (1989): Northwestern University, Evanston, IL, USA

Postdoctoral Fellowship

1990-1991, Northwestern University Cancer Center, Chicago, IL, USA
1991-1992, Washington University, St. Louis, MO, USA

Areas of Interest

Growth factor signaling, extracelluar matrix signaling, metastasis, tumor-stromal interactions, and apoptosis

Research Interests


Warner RB, Najy AJ, Jung YS, Fridman R, Kim S, Kim HRC. Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer Therapy. Sci Rep. 2020 Feb 7;10(1):2099. PMID: 32034211

Bottrell A, Meng YH, Najy AJ, Hurst N Jr, Kim S, Kim CJ, Kim ES, Moon A, Kim EJ, Park SY, Kim HRC. An oncogenic activity of PDGF-C and its splice variant in human breast cancer. Growth Factors. 2019 Aug;37(3-4):131-145. PMID: 31542979

Najy AJ, Dyson G, Jena BP, Lin CY, Kim HR. Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis. Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C293-304. PMID: 26157007

Huang W, Kim HR. Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis. J Biol Chem. 2015 Apr 3;290(14):9162-70. PMID: 25678707

Huang W, Fridman Y, Bonfil RD, Ustach CV, Conley-LaComb MK, Wiesner C, Saliganan A, Cher ML, Kim HR. A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth. Oncogene. 2012 Oct 18;31(42):4527-35. PMID: 22158043

Ustach CV, Huang W, Conley-LaComb MK, Lin CY, Che M, Abrams J, Kim HR. A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer. Cancer Res. 2010 Dec 1;70(23):9631-40. PMID: 21098708

Jung KK, Liu XW, Chirco R, Fridman R, Kim HR. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 2006 Sep 6;25(17):3934-42. PMID: 16917503

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