Avraham Raz, PhD

Avraham Raz, PhD



Avraham Raz, PhD

Office Address

Karmanos Cancer Institute
110 East Warren Avenue
Detriot, MI 48201

Administrative Contact

Vivian Powell
Phone: (313) 578-4331

Position Title

Professor of Pathology, Radiation Oncology and Oncology

Education Training

Areas of Interest

Cancer, metastasis, motility, and carbohydrate-recognition

Research Interests


1.     Wang Y, Balan V, Gao X, Reddy PG, Kho D, Tait L, Raz A. The significance of galectin-3 as a new basal

        cell marker in prostate cancer Cell Death Dis. 2013 : 10.1038/cddis.2013.277. PMID: 23907467

2.     Kho, D, Zhang, T., Balan, V., Wang, Y., Ha, S-W., Xie, Y. and Raz, A. (2013) Secretion of Autocrine

        Motlity Factor (AMF) modulates EGF-induced invasion of breast cancer cells, (submitted

3.     Wang, Ying, Kho, D., Raz, A.* and Xie, Y*.  (2013) Ubiquitylation of autocrine motility factor is regulated

        by the ubiquitin ligase gp78/AMFR and the deubiquitinase USP34, (submitted *co-Corresponding


4.     Funasaka, T., Balan, V., Raz, A., and Wong, R.  (2013) Nucleoporin Nup98 mediates galectin-3 nuclear-

        cytoplasmic trafficking.    Biochem Biophys Res Commun. 434:155-61 PMID:23541576

5.     Balan V, Wang Y, Nangia-Makker P, Kho D, Bajaj M, Smith D, Heilbrun L, Raz A, Heath E. (2013)

        Galectin-3: a possible complementary marker to the PSA blood test. Oncotarget. 4:542-9.


6.     Nangia-Makker P, Raz T, Tait L, Shekhar MP, Li H, Balan V, Makker H, Fridman R, Maddipati K, Raz A.

        (2013) Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of

        matrix metalloproteases Cancer Biol Ther. 14:5 PMID:23380593

7.     Kho, D., Nangia-Makker, P., Balan, V., Hogan, V., Tait, L., Wang, Y. and Raz, A. (2012)  Autocrine

        motility factor promotes HER2 cleavage and signaling in breast cancer cells.  Cancer Cancer 73:1411-9

        PMID: 23248119

8.     Ahmad. A., Ali. S. ,Ahmed, A., Ali. A,. Raz, A., Sakr, W., and Rahman, KM. (2013) 3, 3'-diindolylmethane

        enhances the effectiveness of Herceptin against HER2/neu-expressing breast cancer cells. PLoS ONE

        8:54657 PMID:23372748

9.     Nangia-Makker, P., Balan, V. and Raz, A.  (2013) Galectin-3 binding and metastasis. . Methods Mol Biol.

        878:251-66. PMID:22674139

10.   Wang, Y., Kho, D., Hogan, V., Nangia-Makker, P., and Raz, A. (2012) Galectin-3 regulates p21 stability

        in human prostate cancer cells.  Oncogene  10.1038. PMID:23160381

11.   Braeuer RR, Zigler M, Kamiya T, Dobroff AS, Huang L, Choi W, McConkey DJ, Shoshan E, Mobley AK,

        Song R, Raz A, Bar-Eli M.   (2012) Galectin-3 Contributes to Melanoma Growth and Metastasis via

        Regulation of NFAT1 and Autotaxin.  Cancer Res.. Epub 2012 PMID:22986745

12.   Yanagawa, T., Shinozaki, T., Watanabe, H., Saito, K., Raz, A., and Takagishi, K. (2012) Vascular

        endothelial growth factor-D is a key molecule that enhances lymphatic metastasis of soft tissue

        sarcomas. Exp. Cell Res 318(7);800-808. PMID 22326461

13.   Balan V, Nangia-Makker P, Kho D, Wang Y, Raz A (2012) Tyrosine phosphorylated galectin-3 is

        resistant to PSA cleavage. . J Biol Chem. 2012 Jan 9. [Epub ahead of print] PMID:   22232548


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