School of Medicine

Wayne State University School of Medicine

Profile

Krishna Rao Maddipati
Associate Professor, Director of Lipidomics Core Facility
435 Chemistry Bldg.
5101 Cass Ave.
Wayne State University
Detroit, MI 48202
(313) 577-2088
Areas
Lipidomics, Anticancer agents, PUFA Metabolism
Administrative Contact
Christopher Harris
Phone: (313) 577-1018
Research Interests

Dr. Maddipati is primarily interested in evaluating the role of bioactive lipids, especially metabolites of polyunsaturated fatty acids, in inflammation and related diseases. These include metabolites of ω-6 and ω-3 fatty acids by lipoxygenases such as HETEs, leukotrienes, lipoxins, resolvins, and protectins. Identification of lipid biomarkers in cancer and inflammatory diseases by LC-MS, anticancer drug development targeting arachidonate 12-lipoxygenase, and identification of anticancer and anti-inflammatory compounds in dietary ingredients to provide a biochemical rationale for their beneficial effects are other areas of research interest to our group.

Dr. Maddipati also directs the Lipidomics Core Facility.
 

lipidomics.wayne.edu

Research

Mass Spectrometry based lipidomics, Anticancer drug development, Bioactivelipid metabolism, and inflammation

Education

Ph.D. (1983):    Indian Institute of Science, Bangalore, India

Research Associate, The Pennsylvania State University, University Park, PA (1983-85)

Research Scientist, Wayne State University, Detroit, MI (1985-89)

Publications

[1] M. Al-Shabrawey, R. Mussell, K. Kahook, A. Tawfik, M. Eladl, V. Sarthy, J. Nussbaum, A. El-Marakby, S.Y. Park, Z. Gurel, N. Sheibani, K.R. Maddipati, Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. Diabetes 60 (2011) 614-624.

[2] K.R. Maddipati, S.L. Zhou, Stability and analysis of eicosanoids and docosanoids in tissue culture media. Prostaglandins Other Lipid Mediators 94 (2011) 59-72.

[3] Y. Guo, W. Zhang, C. Giroux, Y. Cai, P. Ekambaram, A.K. Dilly, A. Hsu, S. Zhou, K.R. Maddipati, J. Liu, S. Joshi, S.C. Tucker, M.J. Lee, K.V. Honn, Identification of the orphan G protein coupled receptor GPR31 as a receptor for 12(S)hydroxyeicosatetraenoic acid. J. Biol. Chem. 286 (2011) 33832-33840.

[4] A.A. Elmarakby, J. Faulkner, M. Al-Shabrawey, M.H. Wang, K.R. Maddipati, J.D. Imig, Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301 (2011) R1307-1317.

[5] A.M. Guo, X. Liu, Z. Al-Wahab, K.R. Maddipati, R. Ali-Fehmi, A.G. Scicli, A.R. Munkarah, Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival. Cancer Chemother. Pharmacol. 68 (2011) 1273-1283.

[6] C. Zhang, G. Wang, Z. Zheng, K.R. Maddipati, X. Zhang, G. Dyson, P. Williams, S.A. Duncan, R.J. Kaufman, K. Zhang, Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 55 (2012) 1070-1082.