School of Medicine

Wayne State University School of Medicine

Profile

Mustapha Kandouz, Ph.D.
Assistant Professor

540 E. Canfield Avenue
Scott Hall Building, Room 9207
Phone: 313-577-1386
 

(313) 577-1386
Administrative Contact
Brenda Batts
Research Interests

Dr. Kandouz’ group investigates the role of Intercellular Communication in the regulation of cellular homeostasis during cancer progression, in particular cell death & survival, cell cycle, autophagy, differentiation and invasion.

Areas of Interest:

  • Intercellular Communication (Connexins, Ephrins)
  • Metabolism & Cell death (Bioactive Lipids, Autophagy)
  • Cancer
Education
  • Research Associate & Scientific Director of the Segal Comprehensive Cancer Centre Cell Imaging Platform, Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada, 2010
  • Ph. D in Human Genetics Graduate Program, Université de Paris VII, 1998.
    Project: Hormonal regulation of apoptosis in normal and tumorigenic mammary tissues.
  • Master Degree in Molecular Genetics and Physiology of Microorganisms, Université de Paris XI, 1992.
    Project: Analysis of the genomic context of a reactivated marker in Bacillus subtilis chromosome.
  • Bachelor degree in Molecular Biology and Biochemistry, University of Agadir, Morocco, 1990
     
Publications

 

1) Chukkapalli S, Amessou M, Dilly AK, Dekhil H, Zhao J, Liu Q, Bejna A, Thomas RD, Bandyopadhyay S, Bismar TA, Neill D, Azoulay L, Batist G, Kandouz M. Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells. Exp Cell Res. 2014 Jan 15;320(2):233-46.

2) Chukkapalli S, Amessou M, Dekhil H, Dilly AK, Liu Q, Bandyopadhyay S, Thomas RD, Bejna A, Batist G, Kandouz M. Ehd3, a regulator of vesicular trafficking, is silenced in gliomas and functions as a tumor suppressor by controlling cell cycle arrest and apoptosis. Carcinogenesis.2014 Apr;35(4):877-85.

3) Dilly AK, Ekambaram P, Guo Y, Cai Y, Tucker SC, Fridman R, Kandouz M, Honn KV. Platelet-type 12- lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/AKT/NF-κB. Int J Cancer. 2013 Mar 23.

4) Lövey J, Nie D, Tóvári J, Kenessey I, Tímár J, Kandouz M, Honn KV. Radiosensitivity of Human Prostate Cancer Cells can be Modulated by Inhibition of 12-Lipoxygenase. Cancer Lett. 2013 Mar 20. doi:pii: S0304-3835(13)00240-1.

5) M. Amessou & M. Kandouz. Targeting Intercellular Communication in Cancer Gene Therapy.INTECH "Novel Gene Therapy Approaches”, ISBN 978-953-51-0966-2. Published: February 13, 2013. (Book chapter)

6) M. Kandouz (Corresponding Author), J. Zhao, A. Bier, S. Di Marco, I. Oviedo-Landaverde, I-E Gallouzi, G. Batist. Post-transcriptional regulation of Connexin43 in H-Ras-transformed cells. PLoS One. 2013;8(3):e58500. doi:10.1371/journal.pone.0058500

7) Park JM, Munoz JL, Won BW, Bliss SA, Greco SJ, Patel S, Kandouz M, Rameshwar P. Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells. Cancer Lett. 2013 Apr 30;331(1):84-91. doi: 10.1016/j.canlet.2012.12.007. Epub 2012 Dec 20.

8) Kandouz M, 2012, The Eph/Ephrin family in cancer metastasis: communication at the service of invasion. Cancer Metastasis Rev, 31: 353-73.

9) M. Kandouz. Hopes and Disillusions in Therapeutic Targeting of Intercellular Communication in Cancer. INTECH "Gene Therapy - developments and future perspectives", ISBN 978-953-307-617-1. Published: June 22, 2011. (Book chapter)


10) Kandouz M, Batist G., 2010, Gap junctions and connexins as therapeutic targets in cancer. Expert Opin Ther Targets, 14: 681-92.

11) Kandouz M, Haidara K, Zhao J, Brisson ML, Batist G., 2010, The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways. Cell Cycle, 9: 398-407. 

12) Kandouz M, Alachkar A, Zhang L, Dekhil H, Chehna F, Yasmeen A, Moustafa AE., 2009, Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex. J Ethnopharmacol, 129: 410-5

13) Bier A, Oviedo-Landaverde I, Zhao J, Mamane Y, Kandouz M, Batist G., 2009, Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target. Mol Cancer Ther, 8: 786-93.

14) Yasmeen A, Bismar TA, Kandouz M, Foulkes WD, Desprez PY, Al Moustafa AE., 2007, E6/E7 of HPV type 16 promotes cell invasion and metastasis of human breast cancer cells. Cell Cycle, 6: 2038-42. 

15) Hernandez M, Shao Q, Yang XJ, Luh SP, Kandouz M, Batist G, Laird DW, Alaoui-Jamali MA., 2006, A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. Prostate, 66: 1151-61.

16) M. Kandouz, A. Bier, G. Carystinos, MA. Alaoui-Jamali, G. Batist., 2004, Cx43 pseudogene is expressed in tumor cells and inhibits growth. Oncogene, 23: 4763-70.

17) GD. Carystinos, M. Kandouz, MA. Alaoui-Jamali, G. Batist., 2003, Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence. Mol Pharmacol, 63: 821-31.

18) M. Kandouz,. D. Nie, G.P. Pidgeon, S. Krishnamoorthy, K. Maddipati. and K.V. Honn., 2003, Platelet-type 12-lipoxygenase Activates NF-kB in Prostate Cancer Cells. Prostaglandins and Other Lipid Mediators, 64: 346-54.

19) GP. Pidgeon, M. Kandouz, A. Meram, KV. Honn., 2002, Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res, 62: 2721-7.

20) M. Kandouz, K.V. Honn, 2002, Eicosanoids regulation of transcription factors in PC3 prostate cancer cells. Adv Exp Med Biol, 507: 563-8.

21) M. Kandouz, A. Lombet, J.Y. Perrot, D. Jacob, S. Carvajal, A. Kazem, W. Rostene, A. Therwath, A. Gompel, 1999, Proapoptotic effects of antiestrogens, progestins and androgen in breast cancer cells. J Steroid Biochem Mol Biol, 69: 463-71.

22) A. Gompel, M. Kandouz, M. Siromachkova, A. Lombet, D. Thevenin, M. Mimoun, Ph. Poitout., 1997, The effect of Tibolone on proliferation, differentiation and apoptosis in normal breast cells. Gynecol. Endocrinol, 11: 61-63.

23) M. Kandouz, M. Siromachkova, D. Jacob, B.C. Marquet, A. Therwath and A. Gompel., 1992, Antagonism of Estradiol and Progestin on Bcl-2 expression in breast cancer cell lines. Int J Cancer, 68: 120-125.

24) M. Kandouz, A. Gompel and A. Therwath . bcl-2 protooncogene, Apoptosis and Oncogenesis: an Overview. Int J Oncology, 9, 563-566, 1996