School of Medicine

Wayne State University School of Medicine

Profile

Edi Levi, M.D.
Associate Professor
Department of Pathology
John Dingell VA Medical Center
Detroit, MI 48201
(313) 576-1000 x63428
Areas
Cancer, molecular diagnosis and prognosis

Expertise: Surgical Pathology, Hematopathology
Biography

Dr. Leviís subspecialty expertise is in the field of hematologic cancers, lymphomas and leukemias. Dr. Levi also runs the Flow Cytometry Facility at the Detroit VA Medical Center.

Research Interests

Gastrointestinal Cancers and Lymphomas

Research

Dr. Levi is interested in the biology of gastrointestinal cancers, specifically on the role of cancer stem cells in the pathogenesis of cancers and precursor lesions such as colon polyps and gastric Helicobacter Pylori associated gastritis. Recently we have demonstrated increased expression of cancer stem cells in aging and in response to experimental carcinogenesis utilizing an animal model. We have expanded our studies to precursor lesions in the stomach and have also demonstrated that H. Pylori infection causes an increase in the expression of cancer stem cells in gastric mucosa. Our current and future projects are focused on isolation, quantitation and analysis of cancer stem cells and investigate their prognostic significance. We are utilizing immunohistochemical, molecular and flow cytometric methods to achieve our goals. The study group includes Dr. Adhip Majumdar and Dr. Bhaumik Patel from the Department of Medicine and Oncology.

Residency

Anatomic Pathology Residency (1992-1996)
Northwestern University Medical School
Chicago, IL, USA

Education

M.D (1986)
Hacettepe University Medical School
Ankara, Turkey

PhD in Physiology (1990)
Hacettepe University Medical School
Ankara, Turkey

Postdoctoral Fellowship (1990-1992)
University of Southern California
Los Angeles, CA, USA

Hematopathology Fellowship (1996-1997)
Beth Israel-Deaconess Medical Center
Boston, MA, USA

Research Fellowship in Hematopathology (1997-1999)
Beth Israel-Deaconess Medical Center
Boston, MA, USA
 

Medical Education Responsibilities

Undergraduate Program:
Lab instructor in 2nd year Medical School Students Pathology Courses

Others:
Member of the medical IRB (M1), Wayne State University, 2004-current
Member of the Clinical Investigation Committee, John Dingell VAMC. 2004-current
 

Publications

1: Levi E, Majumdar AP. Cancer stem cells in ulcerative colitis. Onkologie. 2011;34(12):660-2. doi: 10.1159/000334812. Epub 2011 Nov 21. PubMed PMID: 22156444.

2: Nautiyal J, Du J, Yu Y, Kanwar SS, Levi E, Majumdar AP. EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine. Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G655-63. doi: 10.1152/ajpgi.00323.2011. Epub 2012 Jan 26. PubMed PMID: 22281474; PubMed Central PMCID: PMC3330776.

3: Roy S, Levi E, Majumdar AP, Sarkar FH. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J Hematol Oncol. 2012 Sep 19;5:58. doi: 10.1186/1756-8722-5-58. PubMed PMID: 22992310; PubMed Central PMCID: PMC3464169.

4: Levi E, Misra S, Du J, Patel BB, Majumdar AP. Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of  rat colonic crypts. Biochem Biophys Res Commun. 2009 Jul 31;385(3):430-3. doi: 10.1016/j.bbrc.2009.05.080. Epub 2009 May 22. PubMed PMID: 19465005; PubMed Central PMCID: PMC2735198.

5: Patel BB, Yu Y, Du J, Levi E, Phillip PA, Majumdar AP. Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer. Biochem Biophys Res Commun. 2009 Jan 16;378(3):344-7. doi: 10.1016/j.bbrc.2008.10.179. Epub 2008 Nov 14. PubMed PMID: 19010307; PubMed Central PMCID: PMC2644999.