School of Medicine

Wayne State University School of Medicine

Profile

Maria J. Worsham, Ph.D.
Professor
Henry Ford Health System
1 Ford Place, Room
Detroit, MI 48202
313-869-4717
Areas
Otolaryngology/ear, nose & throat research, clinical cytogenetics, and clinical molecular genetics
Other Information

2008 Recipient of the St George National Medal Award, American Cancer Society

Education
  • B.S., Microbiology/Chemistry, St. Xavier's College, Bombay, India 1972
  • M.S., Biology, University of Detroit, Detroit, MI 1976
  • Ph.D., Pathology/Genetics, Wayne State Univ., School of Medicine, Detroit, MI 1993
  • ABMG, Cytogenetics and Molecular Genetics, Medical Genetics Fellowship 1993-1996
  • HLA, HLA Director Training 1996-1998
  • Clinical Cytogenetics Clinical Molecular Genetics, Maintenance of Certification in Clinical Cytogenetics and Clinical Molecular Genetics ABMG October 2006
Publications
  • Worsham MJ, Miller DA, Devries JM, Mitchell AR, Babu VR, Suri V, Weiss L, Van Dyke DL: A dicentric recombinant 9 derived from a paracentric inversion: phenotype, cytogenetics, and molecular analysis of centromeres. Am J Hum Genet 44:115-123, 1989
  • Worsham MJ, Van Dyke DL, Grenman SE, Grenman R, Hopkins MA, Roberts JA, Gasser KM, Schwartz DR, Carey TE: Consistent chromosome abnormalities in squamous carcinoma of the vulva. Genes Chrom Cancer 3:420-432, 1991
  • Worsham MJ, Benninger MJ, Zarbo RJ, Carey TE, Van Dyke DL: Deletion 9p22-pter and loss of Y as primary chromosome abnormalities in a squamous cell carcinoma of the vocal cord. Genes Chrom Cancer 6:58-60, 1993
  • Worsham MJ, Carey TE, Benninger MJ, Gasser K, Kelker W, Zarbo RJ, Van Dyke DL: Clonal cytogenetic evolution in a squamous cell carcinoma of the skin from a Xeroderma Pigmentosum patient, HFH-SCC-XP-1. Genes Chrom Cancer 7:158-64, 1993
  • Carey TE, Worsham MJ, Van Dyke DL: Chromosomal biomarkers in the clonal evolution of head and neck squamous neoplasia. J Cellular Biochem 17F: 213-222, 1993
  • Van Dyke DL, Worsham MJ, Benninger MS, Drumheller T, Carey TE: Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region. Genes Chrom Cancer 9:192-206, 1994
  • Worsham MJ, Wolman SR, Carey TE, Zarbo RJ, Benninger MS, Van Dyke DL: Common clonal origin of synchronous primary head and neck squamous cell carcinomas: analysis by tumor karyotypes and fluorescence in situ hybridization. Hum Path, 26:251-261, 1995, with front cover and Editorial pages: 249-250
  • Buchagen DL, Worsham MJ, Van Dyke DL, Carey TE: Hemizygosity on chromosome 3p correlates with cytogenetic loss in squamous cell carcinoma of the head and neck. Head & Neck, 18:529-537, 1996
  • Worsham MJ, Wolman SR, Zarbo RJ: Molecular genetic fingerprints: Clues to monoclonal origin of multifocal disease. Editorial: Modern Pathology, Modern Path, 9: 163-165, 1996
  • Carey, TE, Frank, CJ, Raval, JR, Jones, JW, McClatchey, KD, Beals, TF, Worsham, MJ, Van Dyke, DL. Identifying changes associated with tumor progression in squamous call carcinoma. Acta Otolaryngol (Stockh) Suppl 529: 00-00, 1997 Acta Otolaryngol (Stockh) Supp529, 1997
  • Jones JW, Raval JF, Beals TF, Worsham MJ, Van Dyke DL, Bradford CR, Carey, TE. Frequent loss of heterozygosity on chromosome 18q in squamous cell cancers: Identification of two regions of loss--18q11.12.3, and 18q21-23. Arch Oto HNS, 123:1-5, 1997
  • Worsham MJ, Zarbo RJ. Molecular Assays for BRCA1 and BRCA2: American Society of Clinical Pathologists Check Sample. DIM, 33-48, 1997
  • Worsham MJ, Nathanson DN, Strunk M, Christopherson P, Wolman SR, Pals G. New BRCA1 Mutation in a Filipino Woman with a Familial History of Breast/ovarian Cancer. Diag Mol Path, Diagn Mol Pathol Jun; 7(3): 164-7, 1998
  • Worsham MJ, Wolman SR, Carey TE, Zarbo RJ, Benninger MS, Van Dyke DL. Chromosomal Aberrations Identified in Culture of Squamous Carcinomas are Confirmed by Fluorescence In Situ Hybridization. J Clin pathol: Molecular Pathology 52:42-46, 1999
  • Worsham MJ. The MLC in Kidney Transplantation. Guidelines for Clinical histocompatibility Practice, pages 35-37, February, 1999
  • Pals G, Pindolia K, Worsham MJ. Rapid and sensitive approach to mutation detection in BRCA1 using real time PCR and melting curve analyses. Molecular Diagnosis, 4:241-246, 1999
  • Pindolia K, Janakiraman N, Kasten-Sportes C, Demanet C, Van Waeyenberge, Worsham MJ: Enhanced Assessment of allogeneic bone marrow transplant engraftment analysis using a panel of ten fluorescent markers in a multiplex polymerase chain reaction. Bone Marrow Transplantation, 13:03:28-37, 1999
  • Yood MU, Johnson CC, Blount A, Abrams J, Wolman E, McCarthy BD, Raju U, Nathanson DS, Worsham M, Wolman SR Race and differences in breast cancer survival in a managed care population. J Natl Cancer Inst, 91:1487-9, 1999
  • Rouba Ali, Nadia Kaisi, Ead Al-Chaty, Roula Badin, G Pals, Chen Young, Maria J. Worsham. Patterns of allelic loss at the BRCA1 locus in Arabic women with breast cancer. International Journal of Molecular Medicine 6: 565-569, 2000
  • Barnabas N, Shurafa M, Van Dyke DL, Wolman SR, Clark D, Worsham MJ. Significance of p53 mutations in CLL: A sequential study of 30 patients. Cancer, 91, 285-293, 2001.
  • Pals G, Young C, Mao H, Worsham MJ. Detection of a single base substitution in a single cell using the LightCycler TM. Journal of Biochemical and Biophysical Methods, 47:121-129, 2001
  • Mao H, Liu H, Xilin Fu, Zhizi F, Abrams J, Worsham MJ Loss of NM23 Expression Predicts Distal Metastases and Poorer Survival for Breast Cancer International Journal of Oncology, Int J Oncol, 18:587-591, 2001
  • Worsham MJ, Wolman SR, Zarbo RJ. Molecular Approaches to identification of tissue contamination in surgical pathology sections. Journal of Molecular Diagnostics, Journal of Molecular Diagnostics, 3:11-15, 2001
  • Herrington S, Worsham M, Southern SA, Mackowiak P, Wolman SR. Loss of sequences on the short arm of chromosome 17 is a late event in squamous carcinoma of the cervix. Molecular Pathology, BMJ.54: 160-164, 2001.
  • Ford ME, Hill DD, Morrison J, Worsham MJ, Havstad SL, Johnson CC. Developing a culturally appropriate breast cancer risk factor survey for African American Women. Oncology Nursing Forum Nurse’s Forum, 29:827-834, 2002
  • Worsham MJ, Pals, G, Raju U, Wolman SR. Establishing a molecular continuum in breast cancer. DNA microarrays and benign breast disease. Cytometry, 47: 56-59, 2002
  • Barnabas N, Amin MB, Pindolia K, Nanavati R, Amin M, Worsham, M. VHL Mutations Compliment Prognostic and Differential Diagnostic Parameters in Renal Cell Carcinoma. Journal of Surg Oncol, 80:52-60, 2002
  • Wirschafter A, Benninger MS, Moss TJ, Umiel T, Blazoff K, Worsham MJ. Micrometastatic tumor detection inptients with head and neck cancer: a preliminary report. Arch Otolaryngol Head Neck Surg, 28: 40-43, 2002
  • Worsham MJ, Pals G, Shouten J, von Spaendonk R, Concus AP, Carey TE, Benninger MS. Delineating Genetic pathways of disease Progression in HNSCC. Arch of Otolaryngol Head and Neck Surg129:702-708, 2003.
  • Salamma ME, DePeralta-Ventrurina, Worsham MJ. Malignant papillary renal tumors with extensive clear cell change: A molecular analysis by microsatellite analysis and fluorescent in-situ hybridization. Archives of Pathology & Laboratory Medicine, 127:1176-1181, 2003
  • Demanet C, Mulder A, Deneys V, Worsham M, Claas F , Ferrone S. Downregulation of HLA-A and Bw6, but not Bw4, allospecificity in human leukemic cells. An escape mechanism from CTL and NK attack? Blood. 2004;103:3122-30, 2004. Epub 2003 Dec 04.
  • Raitanen M, Worsham MJ, Lakkala T, Carey TE, Van Dyke DL, Grenman R, Klemi P, Rantanen V, Isola J, Grenman S. Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization and flow cytometry. Gynecol Oncol. 93:155-63, 2004.
  • Kunjoonju JP, Raitanen M, Grénman S, Tiwari N, Worsham MJ. Identification of individual genes altered in squamous cell carcinoma of the vulva. Genes Chromosomes Cancer. 44:185-93, 2005, PMID: 16001430
  • Worsham MJ, Van Dyke DL, Korf B, Benninger MS. Introduction to Otolaryngic Genetics in Head & Neck Surgery- Otolaryngology, Fourth Edition, Editors Bailey BJ, Johnson JT. 2006
  • Worsham MJ, Benninger MS. Basic Research in Head and Neck Cancer: The Genetics of Head and Neck Cancer in Head and Neck Surgery, Publishers: Orient Longman. In press
  • Worsham MJ, Chen KM, Tiwari N, Pals G, Schouten JP, Sethi S, Benninger MS. Fine mapping of loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4) and MTAP gene loci in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg, Arch Otolaryngol Head Neck Surg. 2006. 132:409-415
  • Worsham MJ, Pals G, Schouten JP, Miller F, Tiwari N, van Spaendonk, Wolman SR. High-resolution mapping of molecular events associated with immortalization, transformation, and progression to breast cancer in the MCF10 model. Breast Cancer Research and Treatment, 96:177-186, 2006 PMID: 16319984; 2005 Nov 30:1-10 PMID: 16319984
  • Worsham MJ, Chen KM, Meduri V, Nygren A, Errami A, Schouten JP, Benninger MS. Epigenetic events of disease progression in HNSCC. Arch Otolaryngol Head Neck Surg. 2006. 132:668-677,. PMID: 16785414
  • Natarajan G, Johnson YR, Zhang F, Chen KM, Worsham MJ. Real time PCR for the Rapid Detection of Group B Streptococcal Colonization in Neonates. Pediatrics, 118:14-22, 2006. PMID: 16818544
  • Raju U, Lu M, Sethi S, Qureshi H, Wolman SR, Worsham, MJ. Molecular Classification of Breast Carcinoma In Situ. Current Genomics, 7, 523-532, 2006
  • Worsham, MJ, Abrams J, Raju U, Kapke A. Lu M, Cheng J, Mott D, Wolman SR. Breast cancer incidence in a cohort of women with benign breast disease from a multi-ethnic primary healthcare population. The Breast Journal, 13(2):115- 21, 2007
  • Stephen JK, Vaught L, Chen KM, Shah V, Schweitzer VP, Gardner G, Benninger MS, Worsham MJ. An epigenetically derived monoclonal origin for recurrent laryngeal papillomas. Arch Otolaryngol Head Neck Surg, 133, 684-692, 2007
  • Stephen JK VL, Chen KM, Sethi S, Shah V, Schweitzer VP, Gardner G, Khan M, Benninger MS, Worsham MJ. Epigenetic events underlie the pathogenesis of sinonasal papillomas. Mod Pathol, 20. 1019-1027, 2007.
  • Worsham MJ, Raju U, Lu M, Kapke A, Cheng J, Wolman SR: Multiplicity of benign breast lesions is a marker of risk for progression to breast cancer, Clin Can Research, 13:5474-5479, 2007.
  • Chen KM, Sawhney R, Khan M, Benninger MS, Hou Z, Sethi S, Stephen, JK, Worsham MJ: Methylation of multiple genes as diagnostic and therapeutic markers in primary HNSCC. Arch Otolaryngol Head Neck Surg, 133, 1132-1138, 2007
  • Saglam O, Shah V, Worsham, MJ. Molecular Differentiation of Early and Late Stage Laryngeal Squamous Cell Carcinoma: An Exploratory Analysis. Diagnostic Molecular Pathology, 16:218-21, 2007
  • Saglam O, Shah V, Worsham MJ. Evaluation of Epithelial Growth Factor Receptor (EGFR) Expression in Benign and Advanced Stage Squamous Cell Carcinomas of the Larynx. Journal of Clinical Ligand Assay, 30, 33-36, 2007
  • Cheng J, Qui S, Raju U, Wolman SR, Worsham MJ: Benign Breast Disease heterogeneity: Association with age, histopathology, and ethnicity. Breast Cancer Research and Treatment, 111:289-296, 2008
  • Worsham MJ, Raju U, Lu M, Kapke A, Cheng J, Shah V, Savera A, Wolman SR. Risk Factors for breast cancer from benign breast disease in a diverse population. Breast Cancer Research and Treatment. DOI: 10.1007/s10549-008-0198-8
  • Stephen JK, Chen KM, Raitanen M, Grénman S, Worsham MJ. DNA hypermethylation profiles in squamous cell carcinoma of the vulva. International Journal of Gynecological Pathology, in press
  • Sethi S, Benninger MS, Lu M, Havard S, Worsham MJ: Noninvasive Genetic Detection of Head and Neck Squamous Cell Carcinoma. An exploratory analysis. Diagnostic Molecular Pathology, in press
  • Sethi S, Lu M, Kapke A, Benninger MS, Worsham MJ: Patient and tumor factors at diagnosis in a multi-ethnic primary head and neck squamous cell carcinoma cohort. Journal of Surgical Oncology, in press