School of Medicine

Wayne State University School of Medicine

Profile

Avraham Raz, Ph.D.
Professor of Pathology, Radiation Oncology and Oncology
Karmanos Cancer Institute
110 East Warren Avenue
Detriot, MI 48201
313-578-4330
Areas
Cancer, metastasis, motility, and carbohydrate-recognition
Administrative Contact
Vivian Powell
Phone: (313) 578-4331
Research Interests

Dr. Raz’s goal is to further the understanding of cancer progression and metastasis using in vitro and in vivo methodologies.

Education

Education

• (1978) – Ph.D.: The Weizmann Institute of Science, Rehovot, Israel. Title of thesis:  Structural and Functional Changes in Cells and Membranes in Response to Drugs and Concanavalin A

• (1972) – M.Sc. (with distinction) Physiology: The Ben-Gurion University of the Negev, and the Hebrew University of Jerusalem, Israel

• (1970) – B.Sc. Biology: The Ben-Gurion University of the Negev, Beer-Sheva, Israel

Postgraduate Training

• (1980-1981) – Research Fellow: Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel

• (1978-1981) – Visiting Scientist: National Cancer Institutes, Frederick Cancer Research Facility, Frederick, MD            

 

Publications

1.     Wang Y, Balan V, Gao X, Reddy PG, Kho D, Tait L, Raz A. The significance of galectin-3 as a new basal

        cell marker in prostate cancer Cell Death Dis. 2013 : 10.1038/cddis.2013.277. PMID: 23907467

2.     Kho, D, Zhang, T., Balan, V., Wang, Y., Ha, S-W., Xie, Y. and Raz, A. (2013) Secretion of Autocrine

        Motlity Factor (AMF) modulates EGF-induced invasion of breast cancer cells, (submitted

3.     Wang, Ying, Kho, D., Raz, A.* and Xie, Y*.  (2013) Ubiquitylation of autocrine motility factor is regulated

        by the ubiquitin ligase gp78/AMFR and the deubiquitinase USP34, (submitted *co-Corresponding

        Authors)

4.     Funasaka, T., Balan, V., Raz, A., and Wong, R.  (2013) Nucleoporin Nup98 mediates galectin-3 nuclear-

        cytoplasmic trafficking.    Biochem Biophys Res Commun. 434:155-61 PMID:23541576

5.     Balan V, Wang Y, Nangia-Makker P, Kho D, Bajaj M, Smith D, Heilbrun L, Raz A, Heath E. (2013)

        Galectin-3: a possible complementary marker to the PSA blood test. Oncotarget. 4:542-9.

        PMID:23625538

6.     Nangia-Makker P, Raz T, Tait L, Shekhar MP, Li H, Balan V, Makker H, Fridman R, Maddipati K, Raz A.

        (2013) Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of

        matrix metalloproteases Cancer Biol Ther. 14:5 PMID:23380593

7.     Kho, D., Nangia-Makker, P., Balan, V., Hogan, V., Tait, L., Wang, Y. and Raz, A. (2012)  Autocrine

        motility factor promotes HER2 cleavage and signaling in breast cancer cells.  Cancer Cancer 73:1411-9

        PMID: 23248119

8.     Ahmad. A., Ali. S. ,Ahmed, A., Ali. A,. Raz, A., Sakr, W., and Rahman, KM. (2013) 3, 3'-diindolylmethane

        enhances the effectiveness of Herceptin against HER2/neu-expressing breast cancer cells. PLoS ONE

        8:54657 PMID:23372748

9.     Nangia-Makker, P., Balan, V. and Raz, A.  (2013) Galectin-3 binding and metastasis. . Methods Mol Biol.

        878:251-66. PMID:22674139

10.   Wang, Y., Kho, D., Hogan, V., Nangia-Makker, P., and Raz, A. (2012) Galectin-3 regulates p21 stability

        in human prostate cancer cells.  Oncogene  10.1038. PMID:23160381

11.   Braeuer RR, Zigler M, Kamiya T, Dobroff AS, Huang L, Choi W, McConkey DJ, Shoshan E, Mobley AK,

        Song R, Raz A, Bar-Eli M.   (2012) Galectin-3 Contributes to Melanoma Growth and Metastasis via

        Regulation of NFAT1 and Autotaxin.  Cancer Res.. Epub 2012 PMID:22986745

12.   Yanagawa, T., Shinozaki, T., Watanabe, H., Saito, K., Raz, A., and Takagishi, K. (2012) Vascular

        endothelial growth factor-D is a key molecule that enhances lymphatic metastasis of soft tissue

        sarcomas. Exp. Cell Res 318(7);800-808. PMID 22326461

13.   Balan V, Nangia-Makker P, Kho D, Wang Y, Raz A (2012) Tyrosine phosphorylated galectin-3 is

        resistant to PSA cleavage. . J Biol Chem. 2012 Jan 9. [Epub ahead of print] PMID:   22232548