School of Medicine

Wayne State University School of Medicine

Profile

Sreenivasa R. Chinni, Ph.D.
Associate Professor of Urology and Pathology

Department of Urology,Pathology , abd Oncology 
9200 Scott Hall
540 E. Canfield Ave.
Detroit, MI 48201

(313) 577-1833
Fax: (313) 577-0057
Areas
Cancer
Administrative Contact
Marlene Thompson
Phone: (313) 577- 4871
Research Interests

Prostate Cancer, chromosomal alterations, chemokine and chemokine receptors, and cell signaling and metastasis.

Research

The research focus of Dr. Chinniís laboratory is to understand the molecular mechanism of prostate cancer metastasis. Currently, the Chinni laboratory is studying the role of chemokines and chemokine receptors in tumor cell invasion and metastasis using in vitro and in vivo preclinical models of metastasis. Dr. Chinni recently found that chemokine receptor CXCR4 highly localizes to lipid rich membrane microdomains, activate members of growth factor family receptors and down stream signaling pathways. In tumor cells this transactivation pathway further contributes to intraosseous tumor growth of prostate cancer cells. Other project in the lab is to define molecular targets of recently identified recurrent chromosomal alterations in prostate cancer patients. The Chinni laboratory subsequently identified that androgen activation of common chromosomal translocations, TMPRSS2-ERG induce CXCR4 transcription, and thereby contributing to enhanced invasion and metastasis of prostate cancer cells. Dr. Chinni and colleagues are currently characterizing the functional significance of chromosomal translocations and chemokine receptor expression in prostate cancer metastasis.

Education

Ph.D. (1998): University of Louisville, School of Medicine, Louisville, KY, USA

Postdoctoral Fellowship
1998-2002: Wayne State University, Detroit, MI, USA, in the field of Cancer Biology and Chemoprevention
 

Publications

1. Chinni SR, Li Y, Upadhyay S, Koppolu PK and Fazlul H. Sarkar, 2001, Indole-3-Carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells, Oncogene, 20: 2927-36.

2. Chinni SR
, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD and Cher ML, 2006, CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12, Prostate, 66: 32-48.

3. Bonfil RD, Sabbota A, Nabha S, Dong Z, Meng H, Yamamoto H, Chinni SR, Bernardo MM, Lim IT, Chang M, Filetti LC, Mobashery S, Cher ML, and Fridman R, 2006, Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor, Intl J Cancer, 118: 2721-6.

4. Bonfil, RD, Chinni, SR, Fridman, R, Kim, H-R, Cher, ML, 2007, Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis, Urology Oncol, 25: 407-11.

5. Chinni, SR, Dong Z, Hamilto Y, Bonfil RD, and Cher ML, 2008, CXCL12/CXCR4 trans-activates HER2 in lipid rafts of PC cells and promotes in vivo intra-osseous tumor growth. Mol Cancer Res, 6: 446-57.