School of Medicine

Wayne State University School of Medicine


Rouba Ali-Fehmi, M.D.
Director of the GYN Oncology Tissue Procurement Program, and Director of Surgical Pathology Fellowship Program of Wayne State University and the Karmanos Cancer Institute
Co-Director GYN Oncology Multidisciplinary Team of the Karmanos Cancer Institute
Department of Pathology
Harper University Hospital
3990 John R
Detroit, MI 48201
(313) 966-6405
Gynecologic Pathology, Breast Pathology, Surgical Pathology, and Molecular Markers
Administrative Contact
Brenda Batts
(313) 577-1102

Rouba Ali-Fehmi, MD is a Professor of Pathology and the Vice Chair for Translational Research at the Wayne State University School of Medicine, the Detroit Medical Center and Karmanos Cancer Center. Having completed her residency at Case Western University, she joined a two year fellowship in Gynecological Pathology at Wayne State University. Dr. Ali-Fehmi is also the director of the surgical pathology fellowship program. In addition to her recognized skills as a highly talented surgical pathologist, she enjoys extensive diagnostic expertise in gynecological and breast pathology in particular. She is an excellent teacher and mentor for our surgical pathology fellows. Dr. Ali-Fehmi is a co-investigator on several funded grants including research focusing on the molecular epidemiology of endometrial carcinoma, inflammatory markers regulating ovarian cancer progression. She has authored and coauthored over 120 peer reviewed manuscripts and has been an inspiring mentor for numerous trainees and junior faculty.

Joined the Department: 1998
Expertise: Gynecological Pathology, Breast Pathology
ContactsEmail:  Office Phone: 313-966-6405

Research Interests

Tumor markers of ovarian cancer, endometrial cancer and breast cancer.


Dr. Ali-Fehmi has been interested in the histopathology and biological characteristics of ovarian and uterine malignancy. Dr. Ali has been actively involved in multiple clinical trials as an expert pathologist. Dr. Ali-Fehmi is also interested in genetic changes and expression profiling of markers for the diagnosis and prognosis of ovarian carcinoma. Dr. Ali-Fehmi is currently an investigator on several funded research projects that involve underlying molecular mechanisms of ovarian tumor progression and metastasis.


(1995-1998) Anatomic Pathology
Case Western Reserve University, University Hospitals of Cleveland
Cleveland, Ohio, USA


M.D. (1989)
Damascus University School of Medicine
Damascus, Syria

Fellowship in Obstetric-Gynecological Pathology (1998-2000)
Detroit Medical Center - Hutzel
Detroit, MI, USA

Fellowship in Cytopathology (2000 to 2001)
Detroit Medical Center - Hutzel Hospital
Detroit, MI, USA

Board Certified in Anatomic Pathology


Medical Education Responsibilities

Undergraduate Program:

Director of the Endocrine Pathophysiology unit in the medical school second year course
Lab instructor for the medical school second year Pathophysiology and Pathophysiology unit


Teaching and mentoring the pathology residents at Harper University Hospital.


Director of WSU Department of Pathology Annual Course (a full day CME program),
Director of Pathology Education, GYN Pathology Translational Research, Department of OB/GYN
Mentor of the Gynecology Oncology fellows


1. Ali-Fehmi R, Che M, Khalifeh I, Malone JM, Morris R, Lawrence WD, and Munkarah AR, 2003, The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma, Cancer, 98: 1423-9.
2. Ali-Fehmi R, Qureshi F, Lawrence WD, and Jacques S, 2004, Apoptosis, proliferation, and expression of P53 and BCL-2 in endocervical intraepithelial glandular lesions and invasive endocervical adenocarcinoma, Int J Gynecol Pathol, 2: 1-6.
3. Ali-Fehmi R, Khalifeh I, Bandyopadhyay S, Lawrence WD, Silva EG, Liao J, Sarkar F, and Munkarah AR, 2006, Patterns of loss of hetrozygosity (LOH) at 10q123.3 and microsatellite instability (MSI) in ovarian endometriosis, atypical endometriosis and epithelial carcinoma arising in a background of endometriosis, Int J Gynecol Pathol, 25: 223-9.
4. Chatterjee M, Mohapatra S, Ionan A, Bawa G, Ali-Fehmi R, Wang X, Nowak J, Ye B, Nahhas FA, Lu K, Witkin SS, Fishman D, Munkarah A, Morris R, Levin NK, Shirley NN, Tromp G, Abrams J, Draghici S, and Tainsky MA, 2006, Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays, Cancer Res, 66: 1181-90.
5. Arabi H, Guan H, Kumar S, Cote M, Bandyopadhyay S, Bryant C, Shah J, Abdul-Karim FW, Munkarah AR, and Ali-Fehmi R, 2009, Impact of microsatellite instability (MSI) on survival in high grade endometrial carcinoma, Gynecol Oncol, 113: 153-8.